A fatty acid, flavonoids, and steroids from Zingiber penisulare. I. Theilade (zingiberaceae)

The first chemical study of Zingiber penisulare I. Theilade (Zingiberaceae) resulted in the isolation of a fatty acid, eicosanoic acid (1), three kaempferol derivatives, 5-hydroxy-3,4',7-trimethoxyflavone  (2), 4',5-dihydroxy-7-methoxyflavonol (5), and 4',5-dihydroxy-3,7-dimethoxyflavone (6), b-sitosterol (3), and 6b-hydroxystigmast-4-ene-3-one (4). Their chemical structures were determined by spectroscopic analyses. Keywords: Zingiber penisulare; Zingiberaceae; kaempferol; flavonol; stigmastane

Chaotic Compressed Sensing and Its Application to Magnetic Resonance Imaging

Fast image acquisition in magnetic resonance imaging (MRI) is important, due to the need to find ways that help relieve patient’s stress during MRI scans. Methods for fast MRI have been proposed, most notably among them are pMRI (parallel MRI), SWIFT (SWeep Imaging with Fourier Transformation), and compressed sensing (CS) based MRI. Although it promises to significantly reduce acquisition time, applying CS to MRI leads to difficulties with hardware design because of the randomness nature of the measurement matrix used by the conventional CS methods. In this paper, we propose a novel method that combines the above-mentioned three approaches for fast MRI by designing a compound measurement matrix from a series of single measurement matrices corresponding to pMRI, SWIFT, and CS. In our method, the CS measurement matrix is designed to be deterministic via chaotic systems. This chaotic compressed sensing (CCS) measurement matrix, while retaining most features of the random CS matrix, is simpler to realize in hardware. Several compound measurement matrices have been constructed and examined in this work, including CCS-MRI, CCS-pMRI, CCS-SWIFT, and CCS-pSWIFT. Simulation results showed that the proposed method allows an increase in the speed of the MRI acquisition process while not compromising the quality of the acquired MR images

EFFECTS OF SUBSTITUENTS ON CH BOND DISSOCIATION ENTHALPIES OF ENT-KAURANE DITERPENOIDS: A DFT STUDY

C-H bond dissociation enthalpies (BDEs) of seven ent-kaurane diterpenoids extracted from Croton tonkinensis Gagnep. have been investigated by using density functional theory (DFT) method. The calculations were performed at the M05-2X/6-31+G(d) level of theory. Additionally, insight into the effects of different substituents including –NH2, –OH, –NO2, –SH, –CN, –Cl, –CONH2, –CH-(CH3)2, –NHCOCH3, –OCOCH3 and –C2H5 on BDE have also been provided. The results showed that the BDE value of ent-16(S)-18-acetoxy-7b-hydroxykaur-15-one compound is lowest, being 83.5 kcal/mol. Among substituents binding at C16 position of this molecule, –NH2 has the most remarkable influence on the BDE (C-H) value. Indeed, the BDE of C16-H significantly decreases from 83.5 to 68.4 kcal/mol when replacing –CH3 group by –NH2 one at the C16 position. The obtained results may provide more information for organic synthesis of ent-kaurane based – novel antioxidant compounds

Risk Factors of Streptococcus suis Infection in Vietnam. A Case-Control Study

Background: Streptococcus suis infection, an emerging zoonosis, is an increasing public health problem across South East Asia and the most common cause of acute bacterial meningitis in adults in Vietnam. Little is known of the risk factors underlying the disease. Methods and Findings: A case-control study with appropriate hospital and matched community controls for each patient was conducted between May 2006 and June 2009. Potential risk factors were assessed using a standardized questionnaire and investigation of throat and rectal S. suis carriage in cases, controls and their pigs, using real-time PCR and culture of swab samples. We recruited 101 cases of S. suis meningitis, 303 hospital controls and 300 community controls. By multivariate analysis, risk factors identified for S. suis infection as compared to either control group included eating "high risk" dishes, including such dishes as undercooked pig blood and pig intestine (OR1 = 2.22; 95% CI = [1.15-4.28] and OR2 = 4.44; 95% CI = [2.15-9.15]), occupations related to pigs (OR1 = 3.84; 95% CI = [1.32-11.11] and OR2 = 5.52; 95% CI = [1.49-20.39]), and exposures to pigs or pork in the presence of skin injuries (OR1 = 7.48; 95% CI = [1.97-28.44] and OR2 = 15.96; 95% CI = [2.97-85.72]). S. suis specific DNA was detected in rectal and throat swabs of 6 patients and was cultured from 2 rectal samples, but was not detected in such samples of 1522 healthy individuals or patients without S. suis infection. Conclusions: This case control study, the largest prospective epidemiological assessment of this disease, has identified the most important risk factors associated with S. suis bacterial meningitis to be eating 'high risk' dishes popular in parts of Asia, occupational exposure to pigs and pig products, and preparation of pork in the presence of skin lesions. These risk factors can be addressed in public health campaigns aimed at preventing S. suis infectio

EFETIVIDADE DA INTERVENÇÃO EDUCACIONAL DIGICARE NA MELHORIA DAS HABILIDADES DE COACHING CLÍNICO DE ESTUDANTES DE ENFERMAGEM E MEDICINA NO VIETNAME E BANGLADESH: UM PRÉ- E PÓS-ESTUDO EXPLORATÓRIO

Coaching has become an important approach to support self-management of patients with non-communicable diseases (NCDs) in healthcare education. Studies conducted in European countries have emphasized the significance of formal coaching training in enhancing the competencies of healthcare students. However, in Southeast Asia, where NCDs pose a serious public health concern, there is a lack of such training opportunities. To address this issue, an exploratory pre and post study was conducted to evaluate the effectiveness of the DigiCare educational intervention in improving clinical coaching skills. Nursing and medical students from six universities in Vietnam and Bangladesh were invited to participate. The intervention included both theoretical and practical classes with interactive methods and home assignments, with a total duration of over 10 contact hours. Pre- and post-intervention assessments were conducted using the Self-Efficacy and Performance in Self-management Support instrument, which was translated and culturally adapted to both countries. Statistical analysis showed a significant improvement in students’ overall competence scores from before (M = 2.6, SD = .67) to after the intervention (M = 3.05, SD = .55), with a medium effect size (p < .001; d = .73). The DigiCare educational intervention appears to be a low-cost and meaningful addition to the curriculum of both nursing and medical universities across countries, with potential benefits in the development of students’ clinical coaching competencies.O coaching tornou-se uma abordagem importante para apoiar a autogestão de pacientes com doenças não transmissíveis (DNTs) na educação em saúde. Estudos realizados em países europeus têm enfatizado a importância do treinamento formal em coaching para aprimorar as competências dos estudantes de saúde. No entanto, no Sudeste Asiático, onde as DNTs representam uma séria preocupação de saúde pública, há uma falta de oportunidades de treinamento nesse sentido. Para abordar essa questão, foi conduzido um pré- e pós-estudo exploratório para avaliar a eficácia da intervenção educacional DigiCare na melhoria das habilidades de coaching clínico. Estudantes de enfermagem e medicina de seis universidades no Vietname e em Bangladesh foram convidados a participar. A intervenção incluiu aulas teóricas e práticas com métodos interativos e tarefas domiciliares, totalizando mais de 10 horas de contato. Avaliações pré e pós-intervenção foram conduzidas utilizando o instrumento de Autoeficácia e Desempenho no Suporte à Autogestão, que foi traduzido e adaptado culturalmente para ambos os países. Análises estatísticas mostraram uma melhoria significativa nas pontuações gerais de competência dos estudantes, de antes (M = 2,6, DP = 0,67) para depois da intervenção (M = 3,05, DP = 0,55), com um efeito médio (p < 0,001; d = 0,73). A intervenção educacional DigiCare parece ser uma adição de baixo custo e significativa para o currículo de universidades de enfermagem e medicina em diferentes países, com benefícios potenciais no desenvolvimento das competências clínicas de coaching dos estudantes

Early Pandemic Influenza (2009 H1N1) in Ho Chi Minh City, Vietnam: A Clinical Virological and Epidemiological Analysis

Rogier van Doorn and colleagues analyze the initial outbreak, attempts at containment, and establishment of community transmission of pandemic H1N1 influenza in Ho Chi Minh City, Vietnam

An Outbreak of Severe Infections with Community-Acquired MRSA Carrying the Panton-Valentine Leukocidin Following Vaccination

Background: Infections with community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) are emerging worldwide. We investigated an outbreak of severe CA-MRSA infections in children following out-patient vaccination. Methods and Findings: We carried out a field investigation after adverse events following immunization (AEFI) were reported. We reviewed the clinical data from all cases. S. aureus recovered from skin infections and from nasal and throat swabs were analyzed by pulse-field gel electrophoresis, multi locus sequence typing, PCR and microarray. In May 2006, nine children presented with AEFI, ranging from fatal toxic shock syndrome, necrotizing soft tissue infection, purulent abscesses, to fever with rash. All had received a vaccination injection in different health centres in one District of Ho Chi Minh City. Eight children had been vaccinated by the same health care worker (HCW). Deficiencies in vaccine quality, storage practices, or preparation and delivery were not found. Infection control practices were insufficient. CA-MRSA was cultured in four children and from nasal and throat swabs from the HCW. Strains from children and HCW were indistinguishable. All carried the Panton-Valentine leukocidine (PVL), the staphylococcal enterotoxin B gene, the gene complex for staphylococcal-cassette-chromosome mec type V, and were sequence type 59. Strain HCM3A is epidemiologically unrelated to a strain of ST59 prevalent in the USA, althoughthey belong to the same lineage. Conclusions. We describe an outbreak of infections with CA-MRSA in children, transmitted by an asymptomatic colonized HCW during immunization injection. Consistent adherence to injection practice guidelines is needed to prevent CA-MRSA transmission in both in- and outpatient settings

COMO É QUE OS ESTUDANTES DE ENFERMAGEM PERCEBEM A TECNOLOGIA EM SAÚDE? UM ESTUDO DE VALIDAÇÃO PSICOMÉTRICA DO USABILITY EVALUATION QUESTIONNAIRE NO VIETNAME

The rapid advancement of technology has transformed the role of nurses and nursing students in patient care, making it an integral component of healthcare delivery. The use of innovative technologies has become commonplace in healthcare settings, creating a high-tech environment that can enhance nursing care quality and patient experience. It is essential for nursing staff and students to be receptive to incorporating such tools into their practice to ensure safe and efficient use of various forms of healthcare technology. Objective: Given the absence of an existing tool in Vietnam to evaluate healthcare students’ technology acceptance, the aim of our research was to culturally adapt, translate, and validate the Usability Evaluation Questionnaire (UtEQ) among nursing students in Vietnam. Method: We conducted a methodological and cross-sectional study in two phases: translation of the UtEQ to Vietnamese (UtEQ-V) following six stages proposed by Beaton and collaborators, and assessment of its psychometric properties in a non-probability sample of 295 Vietnamese nursing students. Results: The UtEQ-V’s reliability was found to be above 0.8 for all factors (.88–.95), while confirmatory factor analysis showed adequate goodness-of-fit indicators. Conclusion: The UtEQ-V is a reliable and valid instrument that can support nursing educators and researchers to assess students’ technology acceptance during their clinical training.O rápido avanço da tecnologia transformou o papel das enfermeiras e dos estudantes de enfermagem nos cuidados aos pacientes, tornando-o um componente integral da prestação de cuidados de saúde. O uso de tecnologias inovadoras tornou-se comum nos contextos de saúde, criando um ambiente de alta tecnologia que pode melhorar a qualidade dos cuidados de enfermagem e a experiência do paciente. É essencial que a equipa de enfermagem e os estudantes estejam recetivos à incorporação de tais ferramentas na sua prática, a fim de garantir o uso seguro e eficiente de várias formas de tecnologia de saúde. Objetivo: Dada a inexistência de uma ferramenta existente no Vietname para avaliar a aceitação da tecnologia por parte dos estudantes de saúde, o objetivo da nossa investigação foi adaptar culturalmente, traduzir e validar o Questionário de Avaliação da Usabilidade (UtEQ) entre estudantes de enfermagem no Vietname. Método: Realizámos um estudo metodológico e transversal em duas fases: tradução do UtEQ para vietnamita (UtEQ-V) seguindo as seis etapas propostas por Beaton e colaboradores e avaliação das suas propriedades psicométricas numa amostra não probabilística de 295 estudantes de enfermagem vietnamitas. Resultados: A fiabilidade do UtEQ-V revelou-se superior a 0,8 para todos os fatores (.88–.95), enquanto a análise fatorial confirmatória apresentou indicadores adequados de ajustamento. Conclusão: O UtEQ-V é um instrumento fiável e válido que pode apoiar os educadores e os investigadores de enfermagem na avaliação da aceitação da tecnologia pelos estudantes durante o seu treino clínico